Table 3.
Baseline characteristics of study population categorized by baseline C-Alb values and Atorvastatin treatment arm
| All subjects | Subjects in low tertile for C-Alb | |||||
|---|---|---|---|---|---|---|
| Placebo (n=590) |
Statin (n=571) |
P-value | Placebo (n=209) |
Statin (n=178) |
P-value | |
| Age (years) | 66 ± 8 | 66 ± 8 | 0.811 | 65 ± 8 | 65 ± 9 | 0.634 |
| Male | 54 | 55 | 0.800 | 52 | 52 | 0.985 |
| Systolic blood pressure (mmHg) | 145 ± 22 | 146 ± 22 | 0.425 | 144 ± 22 | 146 ± 22 | 0.331 |
| Diastolic blood pressure (mmHg) | 76 ± 11 | 76 ± 11 | 0.718 | 76 ± 11 | 76 ± 11 | 0.830 |
| BMI (kg/m2) | 27.4 ± 5.0 | 27.5 ± 4.6 | 0.921 | 28.3 ± 5.2 | 28.1 ± 4.4 | 0.723 |
| Alkaline phosphatase (IU/L) | 124 ± 57 | 126 ± 67 | 0.591 | 124 ± 54 | 118 ± 44 | 0.222 |
| Troponin T (ng/mL) | 0.09 ± 0.11 | 0.09 ± 0.11 | 0.737 | 0.07 ± 0.08 | 0.08 ± 0.14 | 0.171 |
| NT-Pro-BNP (pg/mL) | 8666 ± 15402 | 7600 ± 11544 | 0.184 | 5502 ± 8854 | 6333 ± 10564 | 0.401 |
| Creatinine kinase (U/L) | 69 ± 59 | 69 ± 60 | 0.941 | 65 ± 70 | 67 ± 69 | 0.817 |
| C-reactive protein (ng/mL) | 10.9 ± 18.0 | 10.3 ± 16.5 | 0.567 | 11.4 ± 16.4 | 10.0 ± 13.6 | 0.376 |
| Total cholesterol (mmol/L) | 220 ± 41 | 219 ± 43 | 0.860 | 220 ± 40 | 228 ± 43 | 0.069 |
| LDL cholesterol (mmol/L) | 127 ± 30 | 125 ± 29 | 0.374 | 122 ± 26 | 128 ± 29 | 0.033 |
| HDL cholesterol (mmol/L) | 37 ± 14 | 36 ± 13 | 0.241 | 34 ± 11 | 35 ± 12 | 0.563 |
| Albumin (g/L) | 3.83 ± 0.3 | 3.80 ± 0.3 | 0.098 | 3.81 ± 0.3 | 3.81 ± 0.3 | 0.977 |
| Hemoglobin (g/L) | 10.9 ± 1.4 | 10.8 ± 1.3 | 0.267 | 11.1 ± 1.4 | 11.0 ± 1.3 | 0.491 |
| Transferrin saturation (%) | 22.4 ± 10.8 | 21.9 ± 12.0 | 0.465 | 22.8 ± 11.4 | 23.1 ± 13.0 | 0.806 |
| Calcium (mmol/L) | 2.3 ± 0.2 | 2.3 ± 0.2 | 0.736 | 2.3 ± 0.2 | 2.4 ± 0.2 | 0.040 |
| Ferritin (pmol/L) | 492 ± 425 | 486 ± 429 | 0.812 | 537 ± 461 | 537 ± 461 | 0.998 |
| Potassium (mmol/L) | 5.1 ± 0.8 | 5.2 ± 0.9 | 0.341 | 5.1 ± 0.8 | 5.1 ± 0.9 | 0.508 |
| Phosphorus (mmol/L) | 6.0 ± 1.6 | 6.0 ± 1.6 | 0.819 | 5.6 ± 1.4 | 5.5 ± 1.4 | 0.644 |
| Platelets (103/μL) | 259 ± 81 | 255 ± 79 | 0.428 | 257 ± 75 | 256 ± 79 | 0.858 |
| Intact parathyroid hormone (ng/L) | 102 ± 126 | 103 ± 119 | 0.887 | 95 ± 141 | 90 ± 95 | 0.684 |
| White blood cells (103/μL) | 8.2 ± 2.5 | 8.1 ± 2.4 | 0.547 | 8.0 ± 2.3 | 7.9 ± 2.2 | 0.640 |
| Urea reduction rate (%) | 62 ± 11 | 62 ± 12 | 0.507 | 64 ± 10 | 64 ± 10 | 0.843 |
| Aspartate aminotransferase (IU/L) | 14 ± 7 | 14 ± 13 | 0.727 | 14 ± 7 | 14 ± 5 | 0.268 |
| HbA1c (%) | 6.7 ± 1.3 | 6.7 ± 1.2 | 0.517 | 6.7 ± 1.3 | 6.8 ± 1.2 | 0.816 |
| Duration of diabetes (years) | 18.8 ± 8.9 | 17.4 ± 8.7 | 0.008 | 17.8 ± 8.6 | 16.9 ± 8.6 | 0.334 |
Data are expressed as mean ± SD for continuous variables and percentages (%) with number of cases for categorical data. Student’s t-test was used to test for differences between groups for continuous variables, Chi square testing was used to test for significant differences between proportions for categorical variable