Table 1.
Sample | Rosuvastatin | PEG 400 | Neusilin US2 | Aerosil 200 | Kollidon CL-F | Mg stearate | Lactose | L f * | |||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
[mg] | [%] | [mg] | [%] | [mg] | [%] | [mg] | [%] | [mg] | [%] | [mg] | [%] | [mg] | [%] | ||
40%w | 10 | 1.5 | 123 | 18.9 | 332.5 | 51.2 | 6.5 | 1.0 | 32.5 | 5.0 | 6.5 | 1.0 | 139.0 | 21.4 | 0.4 |
50%w | 10 | 1.5 | 123 | 18.9 | 266.0 | 40.9 | 5.3 | 0.8 | 32.5 | 5.0 | 6.5 | 1.0 | 206.7 | 31.8 | 0.5 |
60%w | 10 | 1.5 | 123 | 18.9 | 221.7 | 34.1 | 4.4 | 0.7 | 32.5 | 5.0 | 6.5 | 1.0 | 251.9 | 38.8 | 0.6 |
70%w | 10 | 1.5 | 123 | 18.9 | 190.0 | 29.2 | 3.8 | 0.6 | 32.5 | 5.0 | 6.5 | 1.0 | 284.2 | 43.7 | 0.7 |
80%w | 10 | 1.5 | 123 | 18.9 | 166.4 | 25.6 | 3.3 | 0.5 | 32.5 | 5.0 | 6.5 | 1.0 | 308.3 | 47.4 | 0.8 |
90%w | 10 | 1.5 | 123 | 18.9 | 147.8 | 22.7 | 3.0 | 0.5 | 32.5 | 5.0 | 6.5 | 1.0 | 327.2 | 50.3 | 0.9 |
100%w | 10 | 1.5 | 123 | 18.9 | 133.0 | 20.5 | 2.7 | 0.4 | 32.5 | 5.0 | 6.5 | 1.0 | 342.3 | 52.7 | 1.0 |
110%w | 10 | 1.5 | 123 | 18.9 | 121.0 | 18.6 | 2.4 | 0.4 | 32.5 | 5.0 | 6.5 | 1.0 | 354.6 | 54.6 | 1.1 |
120%w | 10 | 1.5 | 123 | 18.9 | 110.8 | 17.1 | 2.2 | 0.3 | 32.5 | 5.0 | 6.5 | 1.0 | 365.0 | 56.2 | 1.2 |
* L f means liquid load factor.