Table 2.
Modularity of the thrombosis network and the identification of modular hubs.
| Modules | Number of nodes | Modular hubs | Mechanisms |
|---|---|---|---|
| 1 | 31 | Thrombin, GPIb-IX-V, vWF, factor Xa | Platelet adhesion signaling and classic coagulation cascade system |
| 2 | 22 | Talin-RIAM complex, GP IIb/IIIa, p-Y419-Src, CSK | Platelet activation and aggregation through GP IIb/IIIa |
| 3 | 21 | Syk, Fyn, GPVI-FcR, Lyn, p-Y348-Syk | Platelet activation through GPVI-FcR and Syk signal |
| 4 | 19 | Thrombin-activated PAR, G-protein Gq, GNB-GNG complex | Accumulation of soluble agonists for platelet recruitment |
| 5 | 18 | Plasmin, CLFM, uPAR, PAI-1 | Fibrin formation and dissolution events |
| 6 | 14 | p-PLCG2, p-SLP-76 | Signalosome formation for promoting full platelet activation through PLCG2 |
| 7 | 10 | Kininogen, kallikrein, C1q bp, prekallikrein | Kallikrein-kinin system |
| 8 | 6 | Src, activated PAR1 | Typical platelet activation signal via ERK |