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. 2015 May 17;2015:932161. doi: 10.1155/2015/932161

Table 1.

Examples of recombinant proteins produced in plants by agroinfiltration.

Plant host Vector Biologic target Development stage References
N. benthamiana Nonviral vector Influenza A H5N1 HA VLP vaccine Phase I/II human trial [38, 39]
N. benthamiana TMV NHL personalized vaccine Phase I human trial [37, 40]
N. benthamiana CPMV BTV 4-component VLP vaccine Preclinical [30]
N. benthamiana (WT, ΔXF) TMV/PVX Tetravalent antibody WNV therapeutic Preclinical [28, 41]
N. benthamiana TMV Cellulases for ethanol production Early development [1, 42]
N. benthamiana TMV/PVX Ebola immune complex-based vaccine Preclinical [27, 43]
N. benthamiana TMV, BeYDV, CPMV HBcAg nonenveloped VLP vaccine Preclinical [19, 44]
Lettuce, N. benthamiana TMV/PVX, BeYDV Ebola therapeutics based on MAb Preclinical [18, 32, 34, 45]
Lettuce, N. benthamiana TMV, BeYDV Norovirus NVCP VLP vaccine Preclinical [19, 34, 46]
Lettuce, N. benthamiana TMV/PVX, BeYDV WNV therapeutics based on MAb Preclinical [17, 28, 34]
Lettuce, N. benthamiana (WT, ΔXF) TMV, BeYDV WNV DIII vaccine Preclinical [31, 34, 47]

HA: hemagglutinin; VLP: virus-like particle; NHL: non-Hodgkin's lymphoma; BTV: bluetongue virus; WT: wild-type; ΔXF: plants with double knockdown of β-1,2-xylose and core α-1,3-fucose; WNV: West Nile virus; HBcAg: hepatitis B core antigen; MAb: monoclonal antibody; NVCP: Norwalk virus capsid protein; DIII: domain III of envelope protein.