Table 2.
The main pharmacokinetic parameters of StA in the plasma of rats after intravenous or intragastric administration in four different ways (mean ± SD, n = 3).
| Parameters | Unit | Formulation 1 | Formulation 2 | Formulation 3 | |
|---|---|---|---|---|---|
| Intragastric | Intravenous | Intravenous | Intragastric | ||
| AUC(0−t) | mg/L·h | 18.38 ± 2.45 | 42.98 ± 4.59 | 67.67 ± 8.70 | 32.02 ± 12.51 |
| MRT(0−t) | h | 12.63 ± 1.24 | 8.58 ± 4.39 | 21.78 ± 2.24 | 11.46 ± 0.60 |
| T 1/2z | h | 12.61 ± 2.82 | 12.19 ± 5.24 | 15.88 ± 1.82 | 16.54 ± 6.95 |
| CLz | L/h/kg | 14.19 ± 2.28 | 578.76 ± 112.33 | 359.37 ± 56.65 | 828.40 ± 238.27 |
| Vz | L/kg | 253.29 ± 68.98 | 9625.04 ± 2762.20 | 8135.47 ± 488.59 | 21330 ± 14355.2 |
| T max | h | 4.167 ± 3.753 | — | — | 1.33 ± 0.58 |
| C max | mg/L | 1.11 ± 0.42 | — | — | 2.73 ± 1.32 |
| AUC(0−t)/dose | kg/L·h | 0.0613 | 1.432 | 2.256 | 1.0675 |
| Bioavailability | — | 4.30% | — | 47.30% | |