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. Author manuscript; available in PMC: 2015 May 31.
Published in final edited form as: Birth Defects Res C Embryo Today. 2011 Sep;93(3):281–287. doi: 10.1002/bdrc.20216

Fig 3.

Fig 3

Oxyq is not a DUSP6 inhibitor in a cell based chemical complementation assay quantifying pERK levels in DUSP expressing cells. HeLa cells were transfected with c-Myc tagged DUSP6. Cells with high levels of c-Myc-tagged DUSP6 were identified based on c-Myc staining. pERK levels were measured in the DUSP expressing cells and a cumulative distribution function (cdf) assembled for each well. Cdfs of each well were compared to a reference distribution from 16 vehicle treated cells. Large KS values denote high dissimilarity from control and indicate high pERK levels in the DUSP expressing cells due to phosphatase inhibition. Data are the mean ± SE of four replicates from a single experiment that was repeated once with identical results.