Table 1.
Clinical characteristics of cases with infective endocarditis in Tikur Anbessa Hospital, Ethiopia, 2008-2013
| Variables | Male | Female | Total No (%) | |
|---|---|---|---|---|
| Age(Yr) | 0-7 years | 1{2.4%} | 7{17.0%} | 8{19.5%} |
| 7 years or more | 11{26.8%} | 22{53.6%} | 33{80.0%} | |
| Underlying disease | CHD | 6{14.6%} | 15{36.6%} | 21{51.2%} |
| RHD | 6{14.6%} | 14{34.1%} | 20{48.8%} | |
| Duke's criteria | Confirmed IE | 6{14.6%} | 12{29.3%} | 18{43.9%} |
| Possible IE | 6{14.6%} | 17{41.5%} | 23{56.1%} | |
| Risk factors for IE | Yes | 1{2.4%} | 6{14.6%} | 7{16.8%} |
| No | 4{9.8%} | 6{14.6%} | 10{24.4%} | |
| †-Missing information | 7{17.1%} | 17{41.5%} | 24{58.6%} | |
| Prior antimicrobial therapy | Yes | 10{24.0%} | 22{53.6%} | 31{75.6%} |
| No | 0{0.0%} | 1{3%} | 1{3%} | |
| †-missing information | 9{21.9%} | |||
| Types of antibiotics taken prior to blood culture | Penicillin group | 2{6.0%} | 10{32.0%} | 12{39.0%} |
| @-Two or more antibiotics | 5{16.0%} | 11{35.0%} | 17{55.0%} | |
| Antibiotics not specified | 2{6.0%} | 2{6.0%} | ||
| Cephalosporin alone | 0{0.0%} | |||
| Duration of prior antibiotic therapy | 1 up to 3 days | 1{3.0%} | 3{9.0%} | 4{13.0} |
| 4 up to 10 days | 4{13.0%} | 3{9.0%} | 7{23.0} | |
| More than 10 days | 4{13.0%} | 14{45.0%} | 18{58.0} | |
| Unknown duration | 1{3.0%} | 1{3.0%} | 2{6.0%} | |
| Blood culture result | &- Positive | 2{5.2%} | 2{5.2%} | 4{13.0%} |
| negative | 7{22.5%} | 20 {64.5%} | 27{87.0%} | |
| †-Missing information | 10 | |||
| Echocardiography | Veg.> = 10mm | 5{16.0%} | 3{9.6% } | 8{25.8%} |
| Veg.<10mm | 2{6.4%} | 8{25.8%} | 10{32%} | |
| No veg.seen | 5{16.0%} | 8{25.8%} | 13{42.0%} | |
| Missing information | 10{24.0%} | |||
| Clinically evident SE | yes | 1{2.8%} | 4{11.0%} | 5{14.3%} |
| no | 9{25.7%} | 21{60%} | 30{85.7%} | |
| †-Missing information | 6 | |||
| Congestive heart failure | yes | 7{17.0%} | 20{49.0%} | 27{66.0%} |
| No | 5{12.2%} | 9{21.0% } | 14{34.0%} |
@
includes-penicillins, cephalosporins, aminoglycosides and antituberculous drugs
&
2 staphylococcus aureus, 2-none typical pathogens for IE
€-blood culture was not done or result missed
†
no.of cases with no information out of the total 41 IE episodes