Figure 7. siRNAs targeting IKKβ intron 15 lead to increased production of LPS-induced IL-6.

RAW264.7 macrophages were treated with either of 2 siRNAs targeting IKKβ intron 15 or control non-targeting siRNA, were subsequently exposed to 20 ng/ml for 6 hours, and then expression of both IKKβ isoforms was monitored by qPCR (A,B) and IL-6 production was monitored by ELISA (C).