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. 2015 Feb 6;11(2):e1004635. doi: 10.1371/journal.ppat.1004635

Fig 4. Reduced T-bet+ Th1-Treg cells in CD11c cre IFNγR2 fl/fl mice resulted in unrestrained IFNγ-mediated Th1 inflammation during T. gondii infection.

Fig 4

(A,B) Histological assessment of ileum from infected CD11c cre IFNγR2 fl/fl and WT control mice (n = 12). (C) ELISA analysis of serum IFNγ levels and (D) PCR analysis of parasite burden in LP at days 8 after infection. (E) Frequencies of total Foxp3+ Treg cells from LP in CD11c cre IFNγR2 fl/fl and WT control mice at day 8 post T. gondii infection. FACS analysis and frequencies of T-bet+ cells in Foxp3+CD4+ Treg cells and IFNγ+ cells in Foxp3-CD4+ Teff cells from LP in CD11c cre IFNγR2 fl/fl (F) without or (G) with Treg cell collapse and their corresponding WT control mice at day 8 post T. gondii infection. FACS data are representative of three to four independent experiments. (*p<0.05; **p<0.01; ***p<0.001).