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. Author manuscript; available in PMC: 2015 May 31.
Published in final edited form as: Circ Cardiovasc Imaging. 2014 Sep 8;7(6):895–904. doi: 10.1161/CIRCIMAGING.114.001857

Figure 6.

Figure 6

In vitro analysis of key metabolic enzymes reveals reduced activity in the failing heart: consistent with in vivo data, pyruvate dehydrogenase, citrate synthase, and carnitine acetyl-transferase activity positively correlated with ejection fraction. Aconitase activity was unaltered with altered ejection fraction, possibly because this enzyme is not a rate-determining step. However, isocitrate dehydrogenase did show reduced activity with reduced cardiac function. Highlighting abnormalities in key enzymes involved in pyruvate oxidation and Krebs cycle flux with reducing ejection fraction.