Table 2. Genetics, imaging, biochemistry, and management of patients with cardiac paraganglioma.
| Pt | Age (yrs) |
Genetics | Biochemistry* | Surgical Resection |
Tumor Size (cm) |
Tumor Location |
Mlt | Mets | Treatment | Died | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SDHB | SDHC | SDHD | CgA | DA | MTX | NE | NMN | VMA | |||||||||
| 1 | 36 | + | 0 | 0 | --- | 0 | --- | + (p, u) | + (p, u) | + (u) | + | 2.9 × 2.2 × 2.4 | L atrium | + | 0 | 0 | 0 |
| 2 | 38 | + | 0 | 0 | --- | --- | + (p, u) | + (p, u) | --- | + | 3 × 2 × 2 | R ventricle | + | 0 | 0 | 0 | |
| 3 | 50 | + | 0 | 0 | --- | 0 | --- | 0 | 0 | --- | + | 8 × 7 | L ventricle | 0 | 0 | 0 | 0 |
| 4 | 33 | 0 | + | 0 | --- | + (u) | --- | + (u) | + (u) | --- | + | 5.3 × 5.6 | R AV groove |
+ | 0 | 0 | 0 |
| 5 | 37 | 0 | + | 0 | --- | 0 | --- | + (u) | + (p) | --- | + | 3.6 | R atrium/AV groove |
+ | 0 | cisplatin/ etoposide |
0 |
| 6 | 46 | 0 | + | 0 | + (p) | + (p) | 0 | 0 | 0 | --- | +** | 3.2 × 2.3 | L atrium | 0 | 0 | CVD (pre- operative) |
+ |
| 7 | 28 | 0 | 0 | + | --- | + (u) | + (u) | + (u) | + (u) | --- | + | 7 × 3 × 2 | L AV groove |
+ | 0 | 0 | 0 |
| 8 | 31 | 0 | 0 | + | + (p) | + (u) | --- | + (p, u) | + (p) | --- | + | 2.5 × 1.9 × 2.1 | R AV groove |
+ | 0 | 0 | 0 |
| 9 | 39 | 0 | 0 | + | + (p) | + (p) | --- | + (p) | + (u) | + (u) | ND | L atrium | + | 0 | 0 | 0 | |
| 10 | 63 | 0 | 0 | + | --- | + (p, u) | --- | + (p, u) | + (p, u) | + (u) | + | 3.5 × 3.4 × 4.2 | R atrium | + | 0 | 0 | 0 |
| 11 | 59 | 0 | --- | 0 | --- | + (u) | --- | + (u) | + (p, u) | --- | + | 6.7 | AV groove | 0 | + | CVD | 0 |
| 12 | 33 | 0 | 0 | 0 | + (p) | + (p, u) | + (p) | + (p, u) | + (p, u) | --- | + | 3.4 cm | L atrium | 0 | 0 | 0 | 0 |
| 13 | 63 | 0 | 0 | 0 | + (p) | 0 | --- | 0 | + (p) | --- | + | 4.3 × 4.0 × 3.5 | R atrium/R ventricle |
+ | 0 | 0 | 0 |
| 14 | 32 | --- | --- | --- | --- | 0 | --- | + (p) | 0 | --- | + | --- | 0 | + | 0 | + | |
| 15 | 40 | --- | --- | --- | --- | 0 | --- | + (p) | 0 | --- | + | L atrium | + | + | radiation | + | |
Abbreviations: ---: not done or not available, AV: atrioventricular, CgA: chromogranin A, CVD: cyclophosphamide/vincristine/dacarbazine chemotherapy, DA: dopamine, L: left, Mets: metastases, Mlt: multiple; MTX: methoxytyramine, NE: norepinephrine, NMN: normetanephrine, p: plasma, R: right, SDHB: succinate dehydrogenase subunit B, SDHC: succinate dehydrogenase subunit C, SDHD: succinate dehydrogenase subunit D, u: urine, VMA: vanillylmandelic acid
*
: Epinephrine and metanephrine values are not listed because they were negative in all tested patients.
**
: Tumor was successfully resected, but patient suffered intraoperative complications after resection and did not survive.