Table 1.

Oxidative stress, non-alcoholic fatty liver disease and atherosclerosis: Highlights and open issues

NAFLD is the most common and emerging chronic liver disease worldwide

NAFLD is considered the hepatic manifestation of the metabolic syndrome

Patients with NAFLD are at increased risk of cardiovascular morbidity and mortality and cardiovascular disease is the major cause of death

Chronic oxidative stress is considered one of the key mechanisms responsible for both liver damage progression in NAFLD and atherosclerotic disease

Therapeutic strategies targeting oxidative stress reduction in patients with NAFLD have been proposed, although based on only one RCT

No trial so far, has evaluated the cardiovascular effects of antioxidant treatment in patients with NAFLD

NAFLD: Non-alcoholic fatty liver disease; RCT: Randomized controlled trial.