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Unloading caused a significant decrease in the cortical volume (CtV) and cortical thickness (CtTh), at the diaphysis of tibias of hindlimb-suspended rats when compared to the controls (HS versus Control; P < 0.05). CtV was partially preserved by swimming exercises (HS + Swim versus HS, P < 0.05; HS + Swim versus HS + WB, P < 0.05) but not by regular weight bearing (HS versus HS + WB, P > 0.05). Different signs indicate significant difference (P < 0.05).
