Table 4.
Mean serum concentrations of biochemical indicators of liver function and damage according to the staging of NAFLD.
| Variables | The staging of NAFLD by liver biopsy | Comparison of staging of NAFLD | P value | ||
|---|---|---|---|---|---|
| Steatosis (n = 31) | Steatohepatitis without fibrosis (n = 17) | Steatohepatitis with fibrosis (n = 2) | |||
| AP (U/L) | 75.1 ± 24.9 | 78.3 ± 20.2 | 73.1 ± 1.4 | Steatosis × steatohepatitis without fibrosis | 0.809 |
| Steatosis × steatohepatitis with fibrosis | 0.892 | ||||
| Steatohepatitis without fibrosis × steatohepatitis with fibrosis | 0.767 | ||||
|
| |||||
| AST (U/L) | 22.9 ± 12.8 | 29.9 ± 26.7 | 30.2 ± 7.6 | Steatosis × steatohepatitis without fibrosis | 0.195 |
| Steatosis × steatohepatitis with fibrosis | 0.547 | ||||
| Steatohepatitis without fibrosis × steatohepatitis with fibrosis | 0.484 | ||||
|
| |||||
| ALT (U/L) | 27.1 ± 15.5 | 28.2 ± 17.5 | 28.9 ± 10.3 | Steatosis × steatohepatitis without fibrosis | 0.216 |
| Steatosis × steatohepatitis with fibrosis | 0.330 | ||||
| Steatohepatitis without fibrosis × steatohepatitis with fibrosis | 0.242 | ||||
|
| |||||
| GGT (U/L) | 29.4 ± 17.8 | 42.6 ± 27.7 | 62.4 ± 14.6 | Steatosis × steatohepatitis without fibrosis | 0.104 |
| Steatosis × steatohepatitis with fibrosis | 0.045 | ||||
| Steatohepatitis without fibrosis × steatohepatitis with fibrosis | 0.566 | ||||
|
| |||||
| Alb (g/dL) | 4.5 ± 0.7 | 3.9 ± 0.3 | 3.3 ± 0.2 | Steatosis × steatohepatitis without fibrosis | 0.236 |
| Steatosis × steatohepatitis with fibrosis | <0.001 | ||||
| Steatohepatitis without fibrosis × steatohepatitis with fibrosis | 0.003 | ||||
Mean and standard deviation; Alb: albumin; ALT: alanine aminotransferase; AP: alkaline phosphatase; AST: aspartate aminotransferase; GGT: gamma-glutamyl transpeptidase.