Figure 3.

Quantitative analysis of T₂-weighted magnetic resonance images. Data obtained from images of tibialis anterior muscle such as those shown in Figure 2, analyzed as described in Materials and Methods, show that injured dysferlin-deficient A/J muscle (gray bars) has a greater T₂ signal than does injured dysferlin-sufficient A/WySnJ muscle (white bars) soon after large-strain injury. At 6 hours after injury, the T₂ signal intensity is decreased in A/J muscle and is statistically indistinguishable from that in A/WySnJ muscle. At 24 and 48 hours, however, the signal in A/J muscle is significantly greater than that in A/WySnJ muscle. By 7 and 14 days after injury, the T₂ signal is decreased in A/J muscle, suggesting that edema resolves by this time. ^∗P < 0.05 versus approximately 30 minutes; ^†P < 0.05 versus 6 hours; and ^‡P < 0.05 between strains.