Figure 4.

Progression of myofiber damage and mononuclear cell infiltration after injury. Hematoxylin and eosin staining of tibialis anterior muscle cross sections reveals that after injury, damaged fibers (blue arrows) appear over several hours and days in dysferlin-deficient A/J muscle. Over time, as myofiber damage becomes more widespread, damaged areas are infiltrated by mononuclear cells (yellow arrows). Myofiber damage and cellular infiltration are low in dysferlin-sufficient A/WySnJ muscle.