Table 5.
Summary of Morphological and IHC Features of S.C. Xenografts∗
| Necrosis | Xenographs from mucin-IHCCA |
Xenographs from mixed-IHCCA |
||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| CD90 |
EpCAM |
LGR5 |
CD133 |
CD13 |
CD90 |
EpCAM |
LGR5 |
CD133 |
CD13 |
|
| Large areas | Small areas | Focal | Large areas | Small areas | Focal | |||||
| Main features | Cordonal growth, pleomorphic cells with giant nuclei, PCNA+, α-SMA+, K19+ | |||||||||
| Histopathological aspects mimicking human CCA features | ||||||||||
| PAS positivity | − | + | + | + | + | − | − | − | − | − |
| Large BD type areas (K19) | − | − | − | + | + | − | − | − | − | − |
| Cholangiolo- type areas (K19) | − | − | − | − | − | + | + | + | + | + |
BD, bile duct; CCA, cholangiocarcinoma; IHC, immunohistochemistry; IHCCA, intrahepatic cholangiocarcinoma.
∗
The table summarizes morphological and IHC features of s.c. xenografts in Figure 5.