Table 2.

Sleep oximetry characteristics

All patients		N	%	Missing	Median	Range
	No of Studies	150			2 per pt	1.0-9.0
	Duration since treatment start (years)				3.3	0.1-15.7
	Duration of final assessment since treatment start (years)		8 pts pre-treatment studies only		4.4	0.1-15.7
	Patients with sleep disordered breathing (present/absent)	36/17	68/32	8 (SDB present in 6/8 with only pre-treatment studies)
	Progression of sleep disordered breathing (yes/no)	15/22	41/59	24
	ODI 4% Post treatment				6.1	0.1-46.0
	Median oxygen saturation Post treatment				95.4	83.9-98.1
	% Time < 90% Oxygen saturation Post treatment				2.2	0.0-30.8
HSCT treated Hurler patient
	No of Studies	106
	Time post treatment start (years)				3.1	0.1-14.9
	Sleep disordered breathing post HSCT present/absent	24/11	69/31	6
	Progression of SDB in patients with multiple studies yes/no	6/19	24/76	16
	No of pre-treatment studies	19			In 14 patients
	Pre-treatment ODI 4%				9.5	1.3-39.9
	Pre-treatment Median oxygen saturation				96.2	81.6-98.5
	Pre-treatment % Time < 90% Oxygen saturation				4.1	0-14.2
	No. of post treatment studies	87			In 35 patients
	ODI 4% Post treatment				5.8	0.2-19.8
	Median oxygen saturation Post treatment				95.4	87.4-99.6
	% Time < 90% Oxygen saturation Post treatment				1.75	0-30.8
ERT treated Attenuated Patients
	No of Studies	44
	Time post treatment start (years)				3.5	0.7-8.0
	Sleep disordered breathing (SDB) present	11/6	65/35
	Progression of SDB yes/no	8/3	73/27	7
	No of pre-treatment studies	4			In 3 patients
	Pre-treatment ODI 4%				5.7	0.2-14.8
	No of post treatment studies	40			In 17 patients
	ODI 4% Post treatment				6.9	0.1-46
	Median oxygen saturation Post treatment				95.1	83.9-98.1
	% Time < 90% Oxygen saturation Post treatment				3.2	0-17.25

N indicates number; SDB, Sleep disordered breathing.

ODI 4%, oxygen desaturation index 4%.