Fig. 8.

Amino acid alignment of segments A, B, and C from the LDL receptor with homologous regions from the EGF precursor and several proteins of the blood clotting system. The number of amino acids comprising the variable region in the middle of each sequence is shown in parentheses. The standard one-letter amino acid abbreviations are used (Fig. 6). Amino acids that are present at a given position in more than 50 percent of the sequences are boxed and shown as a consensus at the bottom line. Cysteine residues (C) are underlined in the consensus sequence. Sequence data for the LDL receptor was taken from (4); sequence data for the other proteins were taken from the original references cited in (13, 23).