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. Author manuscript; available in PMC: 2015 Jun 1.
Published in final edited form as: Annu Rev Biomed Eng. 2014 Jun 2;16:505–532. doi: 10.1146/annurev-bioeng-071813-104908

Figure 5.

Figure 5

The GCX mediates NO production in response to shear stress. Bovine aortic ECs were exposed to a step increase in shear stress from static to 20 dyn/cm2 at time 0 in a parallel-plate flow chamber. The HS GAG component was either partially removed by a heparinase enzyme treatment or left intact, and NO released into the media was monitored over time. Shear-induced NO production was completely blocked by the enzyme treatment. Abbreviations: GAG, glycosaminoglycan; GCX, glycocalyx; HS, heparan sulfate; NO, nitric oxide. (Figure adapted with permission from 64.)