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. 2015 Jun 1;5:10573. doi: 10.1038/srep10573

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(a) An age-related increase of β-catenin protein levels in MSCs. (b) Knockdown of β-catenin protein in MSCs was achieved with β-catenin-siRNA (+), but not with non-silencing control siRNA (−). (c) Knockdown β-catenin proteins with β-catenin siRNA (n = 12) decreased SA-β-Gal⁺ cells (%) in MSCs, compared with control siRNA (n = 11) (*p = 0.001, Mann-Whitney test). (d) Knockdown β-catenin proteins with β-catenin siRNA (n = 6) increased ALP activity in MSCs, compared with control siRNA (n = 7) (*p = 0.02, two-tail unpaired t test with Welch correction).