Table 1.
Subject Baseline Characteristics And Medication Use By Drug Assignment For All Subjects and Those Who Developed Myalgia
| Entire Sample | Myalgic Sample | |||
|---|---|---|---|---|
| ATOR (n=203) | PL (n=217) | ATOR (n=19) | PL (n=10) | |
| Women (n) | 103 | 113 | 11 | 5 |
| Caucasian (n) | 192 | 201 | 18 | 10 |
| Age (years) | 43.6(41.4,45.8) | 44.6(42.4,46.8) | 52.5(47.1,50.9)* | 56.9±8.0 (51.9,61.9)* |
| BMI (kg/m2) | 26.3(25.6,27.0) | 26.5(25.8,27.2) | 24.7(22.8,26.6) | 25.0±3.0(23.1,26.9) |
| VO2max (mL/kg/min) | 34.6(33.3,35.9) | 33.2(31.9,34.5) | 31.0(26.7,35.3) | 30.7(26.0,35.4) |
| Resting SBP (mmHg) | 119.5(117.7,121.3) | 118.3(116.5,120.1) | 122.3(117.4,127.2) | 119.0(112.7,125.3) |
| Resting DBP (mmHg) | 75.5(74.2,76.8) | 75.1(73.8,76.4) | 76.4(73.2,79.6) | 72.6(68.9,76.3) |
| Total-C (mg/dL) | 198.7(193.3,204.1) | 194.8(189.9,199.7) | 215.3(195.9,234.7) | 212.0(195.6,228.4) |
| LDL-C (mg/dL) | 119.0(114.1,123.9) | 116.0(111.8,120.2) | 128.9(110.8,147.0) | 130.2(116.1,144.3) |
| HDL-C (mg/dL) | 57.6(55.2,60.0) | 58.6(56.3,60.9) | 68.7(61.5,75.9)* | 61.0(53.2,68.8) |
| TRIG (mg/dL) | 110.5(102.9,118.1) | 103.1(95.7,110.5) | 88.1(72.4,103.8) | 114.2(73.5,154.9) |
| Medication | ||||
| OTC Pain (n) | 21 | 21 | 3 | 2 |
| Prescription Pain (n) | 5 | 16* | 2 | 2 |
| Blood Pressure (n) | 9 | 15 | 2 | 0 |
| Thyroid (n) | 12 | 13 | 4 | 2 |
| Hormone Therapy (n) | 31 | 18* | 2 | 0 |
Data are presented as point estimates and 95% confidence intervals for atorvastatin (ATOR) vs. placebo (PL) subjects in the entire sample and only in subjects classified as myalgic. BMI = body mass index; VO2max = maximal oxygen uptake; SBP = systolic blood pressure; DBP = diastolic blood pressure; C = cholesterol; LDL = low density lipoprotein; HDL = high density lipoprotein; TRIG = triglycerides. OTC Pain = regular use of over-the-counter pain medications such as nonsteroidal anti-inflammatory drugs and acetaminophen; Prescription Pain = regular use of prescription pain medications; Blood Pressure = used a blood-pressure lowering drug; Thyroid = used a synthetic thyroid drug; hormone therapy = if female, used oral contraceptives or hormone replacement therapy.
indicates significant difference between myalgic and nonmyalgic subjects within a treatment group at p < 0.05.