Table 3.
Absolute (Post-Baseline) Aerobic and Strength Data by Drug Assignment
| ATOR (n=2021) | PL (n=217) | |
|---|---|---|
| Resting RER | 0.0 (−0.01,0.01) | 0.0(−0.03,0.03) |
| VO2max(mL/kg/min) | −0.8(−1.3,−0.3) | −0.8(−1.4,−0.2) |
| VT (mL/kg/min) | −0.9(−1.6,−0.2) | −0.6(−1.6,0.4) |
| Handgrip (kg) | 0.1(−0.5,0.7) | −0.6(−1.3,0.1) |
| Arm Strength (APT; N-M) | ||
| Isom Ext | 0.8(−0.2,1.8) | 0.3(−0.6,1.2) |
| Isom Flex | −0.5(−2.1,1.1) | −0.2(−1.1,0.7) |
| Isok Ext @ 60° /sec | 0.5(−0.2,1.2) | −0.2(−0.9,0.5) |
| Isok Flex @ 60° /sec | 0.0 (−0.6,0.6) | 0.0(−0.6,0.6) |
| Isok Ext @ 180° /sec | 0.5(−0.2,1.2) | 0.6(0.2,1.2) |
| Isok Flex @ 180° /sec | 0.2(−0.6,1.0) | 0.1(−0.5,0.7) |
| Leg Strength (APT; N-M) | ||
| Isom Ext | −2.1(−5.1,0.9) | −0.4(−3.4,2.6) |
| Isom Flex | −1.8(−3.2,−0.4) | −1.3(−2.6,0.0) |
| Isok Ext @ 60° /sec | 1.2(−0.8,3.2) | 0.9(−1.1,2.9) |
| Isok Flex @ 60° /sec | 0.9 (−0.5,2.3) | −0.5(−2.7,1.7) |
| Isok Ext @ 180° /sec | 3.9(2.0,5.8) | 3.8(2.3,5.3) |
| Isok Flex @ 180° /sec | 2.7 (1.5,3.9) | 2.1(1.0,3.2) |
| Knee Endurance Fatigue Index | −0.1(−1.6,1.4) | 0.2(−0.8,1.2) |
Data are presented as point estimates and 95% confidence intervals for atorvastatin (ATOR) vs. placebo (PL) subjects.. RER = Respiratory exchange ratio; VO2max = maximal oxygen uptake; VT = ventilatory threshold; APT = average peak torque; Isom = Isometric; Ext = Extension; Flex = Flexion. There were no significant differences in change scores between ATOR and PL treatment groups.
1
One ATOR subject with myalgia did not complete muscle and aerobic post-testing and thus was not included in analyses.