Table 4.
Absolute (Post-Baseline) Aerobic and Strength Data by Drug Assignment in Myalgic Patients
| ATOR (n=181) | PL (n=10) | |
|---|---|---|
| Resting RER | 0.0(−0.05,0.05) | 0.1(−0.1,0.3) |
| VO2max(mL/kg/min) | −0.5(−1.3,0.3) | −1.3(−2.8,0.2) |
| VT (mL/kg/min) | −2.1(−3.9,0.3) | −2.3(−5.9,1.3) |
| Handgrip (kg) | −1.4(−3.4,0.6) | −1.0(−3.7,1.7) |
| Arm Strength (APT; N-M) | ||
| Isom Ext | −0.4(−4.2,3.4) | 1.1(−2.4,4.6) |
| Isom Flex | −3.2(−7.5,1.1) | 0.7(−3.6,5.0) |
| Isok Ext @ 60° /sec | −2.6 (−6.2,1.0) | 0.3(−1.9,2.5) |
| Isok Flex @ 60° /sec | −3.8(−7.8,0.2)* | 0.8(−1.2,2.8) |
| Isok Ext @ 180° /sec | −1.3(−4.4,1.8) | −0.4(−2.2,1.4)* |
| Isok Flex @ 180° /sec | −0.5(−4.1,3.1) | 0.2(−2.2,3.6) |
| Leg Strength (APT; N-M) | ||
| Isom Ext | −17.3 ± (−25.1,−9.5)* | −21.5(−30.6,−12.4)* |
| Isom Flex | −5.3(−10.4,−0.2) | −4.3(−10.2,1.6) |
| Isok Ext @ 60° /sec | −10.4(−20.2,−0.6)* | −6.6(−14.5,1.3) |
| Isok Flex @ 60° /sec | −3.6(−8.6,1.4)* | −4.6(−8.7,−0.5) |
| Isok Ext @ 180° /sec | −3.0(−8.9,2.9)* | −4.1(−10.1,1.9)* |
| Isok Flex @ 180° /sec | −1.0(−4.6,2.6) | −3.9(−6.8,−1.0)* |
| Knee Endurance Fatigue Index | −2.1(−4.4,0.2) | −3.6(−5.7,−1.5) |
Data are presented as point estimates and 95% confidence intervals for atorvastatin (ATOR) vs. placebo (PL) subjects in subjects classified as myalgic. RER = Respiratory exchange ratio; VO2max = maximal oxygen uptake; VT = ventilatory threshold; APT = average peak torque; Isom = Isometric; Ext = Extension; Flex = Flexion.
*
indicates significant difference in change scores between myalgic and nonmyalgicgroups (from Table 3) within a treatment group at p < 0.05.
1
One ATOR subject with myalgia did not complete muscle and aerobic post-testing and thus was not included in analyses.