Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2015 Jun 1;5:10419. doi: 10.1038/srep10419

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2015, Macmillan Publishers Limited

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

PMC Copyright notice

Detecting single polypeptides with a nanopore. a) Schematic illustration of the apparatus (note that α-HL, peptides and chamber are not drawn to scale). The pore is formed by and the voltage is applied across the pore via a matched pair of Ag-AgCl electrodes. b) Ionic current time series of the open pore. Addition of the CP2a peptide at c) 5 μM, d) 10 μM, or e) 20 μM to the trans side causes randomly occurring transient blockades in the current. The applied potential was +70 mV (a positive voltage drives cations from the trans to the cis compartment) and the solution contained an aqueous electrolyte solution of 2 M KCl, 10 mM HEPES, at pH = 7.3.