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The effect of the applied potential magnitude and polarity on polypeptide-nanopore interactions. The ionic current time series and all-points histograms of the currents for a) ΔV = + 70 mV, b) ΔV = + 100 mV, c) ΔV = − 70 mV, and d) ΔV = − 100 mV. As reflected qualitatively by the amplitude histograms, the blockade probability characterizing the peptide-induced reversible obstructions of the ion current through the pore is voltage-dependent (see text).
