Figure 4:

Simplified diagram of a schematic illustration of the role of DAMPs in the elicitation of adaptive anti-tumour immune responses. Compare also Figure 4 in part 1 of this review.1

DAMPs = damage-associated molecular patterns; ICD = immunogenic cell death; ROS = reactive oxygen species; ER = endoplasmic reticulum; CRT = calreticulin; HMGB1 = high-mobility group box 1; HSPs = heat shock proteins; PERK = protein kinase-like eukaryotic initiation factor 2α kinase; UPR = unfolded protein response; eATP = extracellular adenosine triphosphate; mDC = mature dendritic cell.