Figure 5. Impact of Mycobacterium smegmatis respiratory chain mutations on the susceptibility for bedaquiline.

Strains of M. smegmatis were treated with indicated amounts of bedaquiline for 96 hours and CFU/mL were counted on agar plates after three (wild-type, ΔcydA :: kan) or four days (ΔqcrCAB :: hyg) of incubation at 37 °C. Black bars: wild-type; grey bars: ΔqcrCAB :: hyg; white bars: ΔcydA :: kan. Results represent the means of two independent experiments with standard error of the mean (SEM).