Table 4.

Misfolded Prion Protein (PrP^D) Distribution in the Brains of CWD-Infected Cats, CWD-Infected Cervids, and Cats With Feline Spongiform Encephalopathy (FSE).

Neuroanatomic Location	First Passage (n = 4)	Second Passage (n = 4)	Cervids With CWDa	Cats With FSEa
Telencephalon
Cortical gray matter	0/+	++/+++	+/++	+++
Cortical white matter	0	+	+	NA
Septal nuclei	+	+/++	+/++	NA
Basal nuclei
Caudate nucleus	0/+	++	++	NA
Putamen	0/+	++	++	NA
Diencephalon
Corpus callosum	0	0	+	NA
Thalamic nucleib	0	++/+++	+++	NA
Hypothalamic nucleib	0	+/++	++/+++	NA
Internal capsule	0	++	+	NA
Hippocampus	+/++	++/+++	+	NA
Mesencephalon (midbrain)
Rostral colliculi	0	0/+	++	NA
Substantia nigra	0	++	++	NA
Tegmental field	0	+/++	+/++	NA
Periaqueductal gray matter	0	0/+	++	NA
Metencephalon/myelencephalon				+++
Pontine nuclei	0	+	+/++	NA
Pyramidal tract	0	+	0/+	NA
Raphe nuclei	0	0/+	+/++	NA
Cochlear nuclei	0	++/+++	++	NA
Vestibular nuclei	0	+++	+/++	NA
Parasympathetic nucleus of the vagus	+/++	+++	++	NA
Cerebellum
White matter	0	0	+	0
Molecular layer	0	0/+	+/++	+
Granular layer	0	++/+++	++	+++
Purkinje layer	0	0/+	++	NA

Each neuroanatomic site is scored as described in Table 3. The PrP^D distribution data were extrapolated from previously published reports of chronic wasting disease (CWD) infection in mule deer (see text for references). NA = Not Available.

^aThe PrP^D distribution data for cervids with CWD and cats with FSE were extrapolated from previously published reports (see text for references).

^bThe examined thalamic and hypothalamic sites are identical to those described in Table 3.