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. 2015 May 29;5:3. doi: 10.1186/s13587-015-0018-9

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© Pace-Schott et al.; licensee BioMed Central. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — Comparison of REM activations in individuals with insomnia versus without insomnia. When comparing REM to wake, there is a greater increase in regional cerebral glucose metabolism (¹⁸fluoro-deoxyglucose PET) in an anterior midline region in close proximity to the region of the dACC that has been associated with fear expression (a). However, in a comparison of two different groups, the insomnia group showed lesser increase in the vmPFC, an area associated with the memory and expression of fear extinction (b)