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. 2015 Jun 2;13:173. doi: 10.1186/s12967-015-0525-x

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© Johar et al. 2015

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Network analysis illustrating the function of MICAL1 in autoimmune related processes. Of particular importance in the network is the interaction between protein kinase C mu and MICAL. The MICAL protein is highlighted with a circular yellow dot (as was the case for the A2M receptor in Figures 1 and 2) because it is encoded by the MICAL1 that was part of the user generated input list for the MetaCore network-building algorithm. The mechanistic nature of the protein interactions in the network are as follows: P phosphorylation. The downstream effects exhibited by protein–protein interactions between a given set of nodes are represented by the following: pink activation by phosphorylation, grey phosphorylation with unspecified effect.