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. 2015 Feb 5;156(6):1161–1170. doi: 10.1097/j.pain.0000000000000114

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© 2015 International Association for the Study of Pain

This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License, where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially.

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Mean difference and 95% confidence interval in WOMAC Pain score on a 0-to-100 scale for the effect of local anaesthetic wound infiltration in those randomized to treatment vs standard care. Three analytic models were used: (1) intention to treat with complete case (ITT-CC), (2) intention to treat with missing follow-up data imputed (ITT-imputed), and (3) a per-protocol approach (PP). The primary analysis (Primary) (solid lines) was adjusted for preoperative pain score and surgical approach, and further analyses (Adjusted) (dashed lines) were additionally adjusted for minor imbalances in baseline characteristics. P values are presented for analyses reaching nominal significance P < 0.05.