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. 2015 Apr 7;21(6):1269–1281. doi: 10.1097/MIB.0000000000000375

FIGURE 5.

FIGURE 5

TNF-, PMA-, and LPS-mediated induction of OGR1 in MM6 cells was reversed by simultaneous treatment of cells with kinase and NF-kB inhibitors. A, Kinase inhibitors, A6730 (9 μM), SP600125 (20 μM), and curcumin (25 μM), reduced or abolished TNF- (25 ng/mL), PMA- (25 nM), or LPS-mediated (1 μg/mL) induction of OGR1 in MM6 cells. B, Treatment with NF-kB inhibitor MG-132 (20 μM) significantly reduced TNF-mediated (50 ng/mL) or PMA-mediated (25 nM) induction of OGR1 in MM6 cells. C, AICAR (0.5 nM), BAY-11-7082 (20 μM), CAY10512 (0.3 μM), and SC-514 (25 μM) also reduced TNF- (25 ng/mL), PMA- (25 nM), or LPS (1 μg/mL) mediated induction of OGR1. Asterisks denote significant differences from the respective control (**P < 0.01, ***P < 0.001). Representative data of one of 2 similar experiments shown.