Table 2.

Summary of significant differences in parameters found between groups

	Significant Parameters	Group	Potential Result of Changes
NK cell	↓ CD56dimCD16− CD2+	M v S	Impaired ability to adhere to target cells [24].
	↓ CD56dimCD16− CD18+CD2+	M v S	Reduced NK cells in an active state hence lessened NK cell activation and cytotoxic activity [24, 55].
	↑ CD56dimCD16− CD18+CD11c−	S v C	Decreased adhesive abilities or lower number of activated cells [55].
	↓ CD56brightCD16dim NKp46	S v C, S v M	Reduced recognition and lysis of target cells [41].
	↓ Total SLAM	S v M	Lessened ability of NK cells to undergo cytotoxic activity [40].
CD4+ T cell	↑ Total KIR2DL5	M v S	Inhibition of T cell functions [51].
	↓ Naïve KLRG1	M v C, M v S	Enhanced T cell activation [46].
	↑ Central Memory BTLA4	M v C	Greater inhibitory signalling and modulation of immune responses [52].
CD8+ T cell	↑ CD45RA Effector Memory	M v C	Heightened capacity for cytotoxic activities [43].
	↓ Central Memory LFA-1	M v C	Lack of LFA-1 adhesion required for optimal cytotoxic activity [53].
	↓ Total KLRG1	M v C	Enhanced T cell activation [46].

↓ represents significant reductions and ↑ represents significant increases in the group listed first in the ‘Group’ column compared with the group listed second in the ‘Group’ column. S Severe CFS/ME patients; M Moderate CFS/ME patients; C Controls