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PSP-induced changes in TLR4, TRAF6, NF-κB and AP-1 expressions in spleens of B10 (TLR4+/+) and ScCr (TLR4−/−) tumor-bearing mice. The mRNA level of TLR4 (b), TRAF6 (d), NF-κB (f) and AP-1 (h) in spleens of B10 (TLR4+/+) and ScCr (TLR4−/−) mice were measured by Q-PCR. The protein level of TLR4 (a), TRAF6 (c), NF-κB (e) and AP-1 (g) were tested by Western blot. Data represent the mean ± SD; n = 4-6 mice/ group. *p < 0.05 vs. saline group. ND = not detected
