Representative hepatic western blots for markers of (A) oxidative stress, (B) ER stress, and (C) oxidative capacity (n=10/group). All western blots were run under the same experimental conditions. Treatment groups included a control diet (AIN-76A Mod) and four HFDs differing in the n-6:n-3 (1:1, 5:1, 10:1, and 20:1) consumed for a 20-week period. Diets not sharing a common letter differ significantly from one another (P≤.05). Data are presented as means (±SEM).