Table 2. Pooled results for accuracy of interferon-gamma assays to diagnose tuberculous pleurisy.

	Pleural effusion			Blood
	Total	ELISPOT	ELISA	Total	ELISPOT	ELISA
Number of study	17	7	10	14	6	8
Sensitivity(95% CI)	0.82(0.79–0.85)	0.95(0.93–0.97)	0.65(0.60–0.70)	0.80(0.76–0.83)	0.82(0.78–0.85)	0.76(0.70–0.81)
Heterogeneity*(P)	199.86(<0.001)	7.93(0.24)	67.65(<0.001)	19.09(0.12)	9.99(0.075)	6.17(0.52)
Specificity(95% CI)	0.87(0.84–0.9)	0.84(0.78–0.89)	0.89(0.85–0.93)	0.70(0.65–0.75)	0.77(0.69–0.83)	0.64(0.57–0.71)
Heterogeneity(P)	91.18(<0.001)	50.63(<0.001)	38.25(<0.001)	28.52(0.008)	12.57(0.028)	9.34(0.23)
PLR(95% CI)	4.94(2.60–9.39)	5.62(1.65–19.14)	4.6(2.16–9.82)	2.48(1.95–3.17)	3.21(2.09–4.94)	2.00(1.63–2.45)
Heterogeneity(P)	129.36(<0.001)	94.35(<0.001)	42.71(<0.001)	26.57(0.014)	12.18(0.03)	6.13(0.525)
NLR(95% CI)	0.22(0.13–0.38)	0.08(0.04–0.16)	0.41(0.27–0.62)	0.30(0.24–0.37)	0.22(0.16–0.31)	0.38(0.30–0.50)
Heterogeneity(P)	180.23(<0.001)	12.33(0.06)	48.66(<0.001)	18.02(0.16)	6.13(0.294)	5.23(0.632)
PPV(95% CI)	0.91(0.85–0.96)	0.87(0.8–1.03)	0.96(0.68–1.32)	0.79(0.60–0.87)	0.74(0.64–0.84)	0.84(0.75–1.19)
Heterogeneity(P)	132(<0.001)	46.52(0.03)	61.25(<0.001)	4.27(0.09)	6.79(1.22)	5.76(0.46)
NPV(95% CI)	0.79(0.71–0.85)	0.75(0. 65–0.87)	0.84(0.7–1.41)	0.75(0.62–0.83)	0.72(0.58–0.81)	0.76(0.65–0.88)
Heterogeneity(P)	157(<0.001)	9.68(<0.001)	16.9(<0.001)	4.54(0.07)	7.01(1.13)	11.53(0.06)
DOR(95% CI)	28.37(10.53–76.4)	88.85(16.10–490.43)	14.10(4.56–43.54)	9.96(6.02–16.48)	19.82(11.67–33.66)	5.46(3.46–8.61)
Heterogeneity(P)	81.01(<0.001)	23.47(0.001)	43.65(<0.001)	24.44(0.03)	4.93(0.43)	6.38(0.496)
AUC(SEM)	0.91(0.03)	0.98(0.01)	0.84(0.08)	0.84(0.03)	0.89(0.02)	0.78(0.04)

Notes.

^*Q value.

AUC

area under the curve

DOR

diagnostic odds ratio

ELISPOT

enzyme-linked immunosorbent spot

ELISA

enzyme-linked immunosorbent assay

NLR

negative likelihood ratio

PLR

positive likelihood ratio

PPV

positive predictive value

NPV

negative predictive value