Table 3. Codon-based maximum likelihood and Bayesian analysis for negatively selected sites in exon 4 and in exons 1, 2, and 3 combined.

Statistics with significance level p < 0.05, posterior probability >0.9 and Bayes Factor >50 are boldfaced. Consensus column summarizes methods which found the codon positively selected with significance level p < 0.2. Analysis was made using the Datamonkey server www.datamonkey.org (Delport et al., 2010; Pond, Frost & Muse, 2005).

Codon	SLAC	SLAC	FEL	FEL	REL	REL	FUBAR	FUBAR	Consensus
	dN − dS	p-value	dN − dS	p-value	dN − dS	Bayes F	dN − dS	Post.Pr.	S	F	R	Fu
Negatively selected sites in exon 4
2	−5.63	0.31	−15.55	0.08	−1.41	513.1	−0.63	0.79		–	–
7	−3.09	0.51	−5.92	0.58	−0.38	147.9	−0.133	0.51			–
13	−2.35	0.57	−2.43	0.81	−0.36	10777.7	−0.208	0.53			–
14	−12.35	0.14	−55.82	0.02	−0.67	16734.7	−3.53	0.96	–	–	–	–
31	−2.26	0.58	−2.17	0.83	−0.35	13704.8	−0.146	0.51			–
45	−3.49	0.50	−12.31	0.35	−0.45	102.0	−0.509	0.62			–
46	−9.93	0.12	−17.62	0.06	−1.28	2384580.0	−1.53	0.94	–	–	–	–
58	−5.88	0.37	−8.66	0.36	−0.65	197.32	−0.62	0.66			–
60	−2.18	0.56	−0.63	0.97	−0.02	112811000.0	−0.03	0.34			–
62	0.43	0.73	4.43	0.72	−0.01	52.6	0.40	0.25			–
68	0.04	0.71	1.10	0.92	−0.08	13381.4	0.09	0.32			–
Negatively selected sites in exons 1, 2, and 3 combined
15	−11.59	0.24	−210.0	0.10	−7.08	338.4	−4.50	0.97		–	–	–
17	−15.07	0.11	−345.8	0.02	−7.15	579.5	−5.65	0.98	–	–	–	–
26	−8.34	0.39	−128.4	0.45	−6.38	68.0	−2.93	0.73			–
47	−7.54	0.33	−131.9	0.15	−7.1	501.4	−2.06	0.83		–	–