Figure 2. Depiction of the associations among UPSIT, EC thickness, and amyloid.

In the multivariate model with UPSIT-40 as the dependent variable (n = 165), in PiB-positive individuals, thinner EC was significantly associated with worse odor identification (interaction term, p = 0.02). The slope for the PiB-positive individuals was significant (β = 2.6, 95% confidence interval: 0.88, 4.4; p = 0.004), while the slope for PiB-negative individuals was not (β = 0.038, 95% confidence interval: −1.3, 1.4; p = 0.96). EC = entorhinal cortex; PiB = Pittsburgh compound B (PiB status 1.20 distribution volume ratio positivity cutoff); UPSIT = 40-item University of Pennsylvania Smell Identification Test.