TABLE 5.
aHRs of Offspring Being Diagnosed With ASD After Febrile Episode Until Week 32 in Pregnancy
| Febrile Episode | ASD
|
Infantile Autism
|
|||
|---|---|---|---|---|---|
| No. Exposed ASD/Non-ASD | Crude HR (95% CI) | aHRa (95% CI) | No. Exposed Infantile Autism/Non–Infantile Autism | aHRa (95% CI) | |
| Febrile episode | 234/22 894 | 1.0 (0.8–1.1) | 1.0 (0.9–1.2) | 101/23 027 | 1.4 (1.0–1.8) |
| No. of episodes | |||||
| 1–3 | 163/15 864 | 1.0 (0.8–1.2) | 1.0 (0.9–1.2) | 93/20 552 | 1.4 (1.1–1.8) |
| ≥4 | 71/7030 | 1.0 (0.7–1.5) | 1.0 (0.6–1.6) | 8/2475 | 0.7 (0.3–2.0) |
| Length of the longest episode, d | |||||
| 1–2 | 140/14 028 | 1.0 (0.8–1.2) | 1.0 (0.8–1.2) | 59/14 109 | 1.3 (0.9–1.8) |
| 3–6 | 73/7282 | 1.0 (0.8–1.2) | 1.0 (0.8–1.3) | 28/7327 | 1.2 (0.8–1.8) |
| ≥7 | 20/1355 | 1.4 (0.9–2.2) | 1.6 (1.0–2.5) | 14/1361 | 3.2 (1.8–5.6) |
| The highest temperature | |||||
| <38.5°C | 33/3280 | 1.0 (0.7–1.4) | 1.1 (0.8–1.6) | 12/3301 | 1.3 (0.7–2.3) |
| ≥38.5°C | 105/10 040 | 1.0 (0.8–1.2) | 1.0 (0.8–1.2) | 47/10 098 | 1.3 (0.9–1.8) |
| Febrile episode with | |||||
| Respiratory symptomsb | 122/10 697 | 1.1 (0.9–1.4) | 1.1 (0.9–1.4) | 55/10 764 | 1.5 (1.1–2.0) |
| Gastrointestinal symptomsc | 65/5371 | 1.2 (0.9–1.5) | 1.2 (0.9–1.6) | 24/5412 | 1.1 (0.7–1.9) |
| General symptomsd | 112/10 658 | 1.0 (0.8–1.2) | 1.0 (0.8–1.3) | 44/10 726 | 1.2 (0.8–1.6) |
a
Adjusted for maternal age, paternal age, maternal smoking during pregnancy, parity, gender, parents’ educational status, and the parents’ psychiatric condition. Data were analyzed in strata by year of birth.
b
Include cold, cough, sore throat, and pain in ears.
c
Include diarrhea, pain in stomach, and vomiting.
d
Include headache, pain in joints, pain in muscles, pain behind ears, and tiredness.