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. 2015 Jun 1;212(6):953–970. doi: 10.1084/jem.20150002

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© 2015 Thompson et al.

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Figure 3. — Loss of Dyrk1a adversely affects T cell development. (A) Mean thymocyte numbers in Control and CKO mice were assessed 2 and 4 wk after pI:pC treatment; n = 6 mice per genotype, pooled from 3 independent cohorts of 2 mice per genotype. (B) Representative flow cytometry analysis of total (left) and CD4⁻/CD8⁻ double-negative (DN, right) thymocytes is shown. Numbers indicate the percentages in each gate; mean absolute numbers were quantified in (C); n = 6 mice per genotype, pooled from 3 independent cohorts of 2 mice per genotype. (D) Mean percentage of Annexin V⁺ cells was assessed from CD4⁺CD8⁺ double-positive (DP) thymocytes 2 wk after pI:pC treatment; n = 4 mice per genotype. Data are representative of 2 independent cohorts of n = 4 mice per genotype. (E) Mean total thymocyte numbers and representative flow cytometry analysis (F) of thymi from Dyrk1a^wt/wt Lck-Cre⁺ (Control) and Dyrk1a^f/f Lck-Cre⁺ (CKO) mice are shown; n = 6 mice per genotype, pooled from 3 independent cohorts of 2 mice per genotype. **, P < 0.01; ****, P < 0.0001.