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. 2015 Jun 1;212(6):855–864. doi: 10.1084/jem.20141992

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© 2015 Wilson et al.

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Figure 5. — STAT3-deficient MAIT cells do not respond to Th17-polarizing stimuli. Sorted δ2⁺ and δ2⁻ γδ T, MAIT, and total CD4⁺ T cells from normal controls or STAT3^MUT patients were cultured under Th0 (TAE beads), Th1 (TAE + IL-12), and Th17 (TAE + IL-1β/IL-6/IL-23/TGFβ) conditions. (A–D) After 5 d, secretion of IL-17A (A), IL-17F (B), IFNγ (C), and Granzyme B (D) was determined. (E) Absolute cell numbers in each culture were also determined at this time. Graphs show mean ± SEM (n = 4–9); *, P < 0.05; **, P < 0.01; ***, P < 0.001; ****, P < 0.0001.