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. 2015 Jun 1;212(6):927–938. doi: 10.1084/jem.20142384

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© 2015 Kim et al.

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Figure 1. — Autoinflammatory disease in Wdr1^rd/rd mice is IL-1 independent, but IL-18 dependent. (a and b) Serum cytokines/chemokines from wild-type (Wdr1^+/+) and Wdr1^rd/rd mice were analyzed by Bioplex (a) or for IL-1β and IL-18 by ELISA (b). n = 5–6. *, P < 0.05; **, P < 0.01; ***, P < 0.001 by unpaired t test, corrected for multiple comparisons. (c) Incidence of inflammation in tail or ears for Wdr1^rd/rd, Wdr1^rd/rdIL-1R^−/−, or Wdr1^rd/rdIL-18^−/− mice. ****, P < 0.0001 by Gehan-Breslow-Wilcoxon test. (d) Incidence of inflammation after reconstitution of lethally irradiated mice with BM of the indicated genotypes (donor BM→irradiated host). ****, P < 0.0001 by Gehan-Breslow-Wilcoxon test. (e) Serum IL-18 from the mice shown in panel d was analyzed by ELISA. n = 4 or 6. Error bars represent means ± SEM. *, P < 0.05 by one-tailed unpaired t test. Except for disease incidence, all data are representative of two to four independent experiments.