Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2015 Jun 1;212(6):927–938. doi: 10.1084/jem.20142384

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2015 Kim et al.

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).

PMC Copyright notice

Figure 7. — Pyrin-dependent IL-18 secretion and inflammation in Wdr1 mutant mice. (a) Serum IL-18 from WT, Wdr1^rd/rd, and Wdr1^rd/rdCasp1^−/− mice. n = 5–13. *, P < 0.05; **, P < 0.01 by unpaired t test. (b) Incidence of inflammation from Wdr1^rd/rd, Wdr1^rd/rdCasp1^−/−, and Wdr1^rd/rdCasp11^−/− mice. ****, P < 0.0001 by Gehan-Breslow-Wilcoxon test. (c) Incidence of inflammation from Wdr1^rd/rd, Wdr1^rd/rdNlrp1^−/−, Wdr1^rd/rdNlrp3^−/−, and Wdr1^rd/rdAsc^−/− mice. ***, P < 0.001 by Gehan-Breslow-Wilcoxon test. (d) Incidence of inflammation from Wdr1^rd/rd, Wdr1^rd/rdNlrc4^−/−, Wdr1^rd/rdAim2^−/−, and Wdr1^rd/rdPyrin^−/− mice. ****, P < 0.0001 by Gehan-Breslow-Wilcoxon test. (e) Serum IL-18 from WT, Pyrin^−/−, Wdr1^rd/rd, and Wdr1^rd/rdPyrin^−/− mice. (f) Wdr1^rd/rd mice were rederived in a gnotobiotic facility to establish any potential role for commensal microbes in the inflammatory pathology caused by a loss of Wdr. This is compared with conventionally housed Wdr1^rd/rd and Wdr1^rd/rdIL-18^−/− mice. ***, P < 0.001; ****, P < 0.0001 by Gehan-Breslow-Wilcoxon test. Except for disease incidence, data are representative of two to four independent experiments. n = 5–25. Error bars represent means ± SEM.