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. 2015 Jun 1;10(6):e0128704. doi: 10.1371/journal.pone.0128704

Fig 4. Model of the molecular mechanism of stathmin interplay with Vinca alkaloids and taxanes.

Fig 4

Left side of the cartoon depicts a situation in which the level of expression is normal, i.e. not higher in the tumor that in the surrounding cells: stabilizing effect of paclitaxel and destabilizing effect of Vinca alkaloids, while right side depicts a situation where stathmin is overexpressed: loss of paclitaxel stabilizing effect and increase of Vinca alkaloids destabilizing effect.