Table 3.
Between- and Within-Group Differences in Cholesterol and CRP in Women Receiving O3-FAs Versus Placebo
| Treatment | Baseline |
Week 12 |
Week 24 |
Difference (week 12 − baseline) |
||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| No. | Mean | SD | No. | Mean | SD | No. | Mean | SD | No. | Mean | SD | P* | P† | |
| Cholesterol, mg/dL | ||||||||||||||
| All | 175 | 201.7 | 38.7 | 172 | 201.3 | 40.3 | 146 | 201.3 | 38.0 | 169 | −1.0 | 27.8 | .66 | |
| O3-FAs | 85 | 201.6 | 37.5 | 80 | 200.9 | 39.2 | 74 | 202.9 | 34.9 | 79 | −2.0 | 31.2 | .56 | |
| Placebo | 90 | 201.9 | 40.0 | 92 | 201.7 | 41.5 | 72 | 199.7 | 41.2 | 90 | −0.1 | 24.5 | .97 | |
| CRP, mg/L | ||||||||||||||
| All | 175 | 4.1 | 5.5 | 172 | 5.2 | 8.9 | 146 | 4.1 | 5.5 | 169 | 1.1 | 8.2 | .71 | |
| O3-FAs | 85 | 4.1 | 4.4 | 80 | 5.5 | 9.3 | 74 | 4.0 | 5.5 | 79 | 1.3 | 7.8 | .13 | |
| Placebo | 90 | 4.2 | 6.3 | 92 | 5.0 | 8.6 | 72 | 4.3 | 5.6 | 90 | 0.9 | 8.6 | .34 | |
| HDL, mg/dL | ||||||||||||||
| All | 175 | 55.5 | 16.9 | 172 | 57.4 | 17.8 | 146 | 57.3 | 18.7 | 169 | 1.9 | 8.9 | .25 | |
| O3-FAs | 85 | 56.2 | 16.6 | 80 | 59.1 | 18.5 | 74 | 59.6 | 19.3 | 79 | 2.7 | 8.8 | .007 | |
| Placebo | 90 | 54.8 | 17.2 | 92 | 55.8 | 17.1 | 72 | 55.1 | 18.0 | 90 | 1.1 | 9.0 | .23 | |
| LDL, mg/dL | ||||||||||||||
| All | 172 | 117.0 | 31.7 | 169 | 116.6 | 33.3 | 143 | 116.1 | 30.8 | 165 | −0.7 | 23.4 | .60 | |
| O3-FAs | 85 | 117.7 | 32.9 | 79 | 118.8 | 35.1 | 73 | 118.4 | 30.3 | 78 | 0.3 | 27.5 | .93 | |
| Placebo | 87 | 116.4 | 30.6 | 90 | 114.6 | 31.7 | 70 | 113.7 | 31.3 | 87 | −1.7 | 19.2 | .42 | |
| Triglycerides, mg/dL | ||||||||||||||
| All | 175 | 144.6 | 88.3 | 172 | 134.4 | 84.1 | 146 | 134.0 | 79.1 | 169 | −10.3 | 56.8 | .01 | |
| O3-FAs | 85 | 138.4 | 69.3 | 80 | 115.9 | 61.4 | 74 | 122.5 | 62.7 | 79 | −22.1 | 52.1 | < .001 | |
| Placebo | 90 | 150.5 | 103.2 | 92 | 150.5 | 97.2 | 72 | 145.7 | 92.1 | 90 | 0.0 | 59.0 | 1.00 | |
Abbreviations: CRP, C-reactive protein; O3-FA, omega-3 fatty acid; SD, standard deviation.
*
P value for paired t tests for difference between baseline and week-12 measures within treatment arm.
†
P value for unpaired t tests for difference in change measures between treatment arms.