Table 1.
Kinetic constants of wild-type and engineered Shp2 assayed with pNPP.
| enzyme | kcat(s−1) | KM (mM) | kcat/KM (mM−1 s−1) |
|---|---|---|---|
| Wild-type Shp2 | 8.7 ± 0.54 | 5.6 ± 0.027 | 1.6 |
| V368C Shp2 | 13 ± 1.7 | 4.1 ± 0.83 | 3.2 |
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