Table 1.
Effects of GLI on individual hindlimb skeletal muscle BFs and VCs for the rest group
| BF, ml·min−1·100 g−1 |
VC, ml·min−1·100 g−1·mmHg−1 |
||||
|---|---|---|---|---|---|
| Percentage of Type I + IIa Fibers According to Delp and Duan (13) | Control | GLI | Control | GLI | |
| Ankle extensors | |||||
| Soleus | 91 | 115 ± 20 | 91 ± 28 | 0.88 ± 0.15 | 0.62 ± 0.21 |
| Plantaris | 20 | 18 ± 4 | 16 ± 4 | 0.4 ± 0.03 | 0.11 ± 0.03 |
| Gastrocnemius, red | 86 | 57 ± 18 | 46 ± 22 | 0.44 ± 0.15 | 0.30 ± 0.14 |
| Gastrocnemius, white | 0 | 11 ± 3 | 16 ± 5 | 0.09 ± 0.03 | 0.10 ± 0.03 |
| Gastrocnemius, mixed | 9 | 20 ± 5 | 20 ± 9 | 0.16 ± 0.04 | 0.13 ± 0.06 |
| Tibialis posterior | 27 | 26 ± 10 | 11 ± 4 | 0.21 ± 0.08 | 0.07 ± 0.02 |
| Flexor digitorum longus | 32 | 57 ± 31 | 65 ± 48 | 0.41 ± 0.21 | 0.38 ± 0.26 |
| Flexor halicus longus | 29 | 16 ± 4 | 9 ± 2 | 0.12 ± 0.03 | 0.06 ± 0.01 |
| Ankle flexors | |||||
| Tibialis anterior, red | 37 | 59 ± 17 | 33 ± 12 | 0.45 ± 0.13 | 0.20 ± 0.06 |
| Tibialis anterior, white | 20 | 24 ± 8 | 17 ± 4 | 0.19 ± 0.06 | 0.11 ± 0.03 |
| Extensor digitorum longus | 24 | 22 ± 5 | 20 ± 5 | 0.16 ± 0.04 | 0.13 ± 0.03 |
| Peroneals | 33 | 27 ± 7 | 18 ± 7 | 0.22 ± 0.06 | 0.12 ± 0.04 |
| Knee extensors | |||||
| Vastus intermedius | 96 | 134 ± 34 | 101 ± 44 | 1.04 ± 0.28 | 0.70 ± 0.30 |
| Vastus medialis | 18 | 38 ± 14 | 30 ± 12 | 0.30 ± 0.12 | 0.20 ± 0.08 |
| Vastus lateralis, red | 65 | 88 ± 37 | 87 ± 45 | 0.71 ± 0.31 | 0.59 ± 0.29 |
| Vastus lateralis, white | 0 | 10 ± 2 | 14 ± 4 | 0.08 ± 0.01 | 0.10 ± 0.03 |
| Vastus lateralis, mixed | 11 | 24 ± 8 | 24 ± 8 | 0.19 ± 0.07 | 0.16 ± 0.05 |
| Rectus femoris, red | 34 | 38 ± 11 | 28 ± 13 | 0.29 ± 0.08 | 0.18 ± 0.09 |
| Rectus femoris, white | 0 | 21 ± 4 | 16 ± 5 | 0.17 ± 0.04 | 0.11 ± 0.03 |
| Knee flexors | |||||
| Biceps femoris anterior | 0 | 12 ± 3 | 12 ± 2 | 0.10 ± 0.03 | 0.08 ± 0.02 |
| Biceps femoris posterior | 8 | 20 ± 7 | 16 ± 5 | 0.16 ± 0.05 | 0.10 ± 0.03 |
| Semitendinosus | 17 | 23 ± 7 | 15 ± 4 | 0.19 ± 0.06 | 0.10 ± 0.02 |
| Semimembranosus, red | 28 | 25 ± 12 | 17 ± 4 | 0.20 ± 0.09 | 0.12 ± 0.03 |
| Semimembranosus, white | 0 | 13 ± 2 | 10 ± 1 | 0.10 ± 0.02 | 0.07 ± 0.01 |
| Thigh adductors | |||||
| Adductor longus | 95 | 97 ± 14 | 74 ± 20 | 0.76 ± 0.11 | 0.50 ± 0.15 |
| Adductor magnus and brevis | 11 | 31 ± 14 | 22 ± 7 | 0.25 ± 0.11 | 0.15 ± 0.05 |
| Gracilis | 23 | 23 ± 9 | 14 ± 3 | 0.18 ± 0.07 | 0.09 ± 0.02 |
| Pectineus | 31 | 29 ± 10 | 20 ± 6 | 0.23 ± 0.08 | 0.13 ± 0.04 |
Data are means ± SE; n = 6 at rest and 8 during exercise.
GLI, glibenclamide; BF, blood flow; VC, vascular conductance.
*
P < 0.05 vs. control.