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. 2015 Mar 20;308(11):H1391–H1401. doi: 10.1152/ajpheart.00390.2014

Fig. 3.

Fig. 3.

HDAC inhibition represses MMP-2 and MMP-9 levels in the infarct zone of the 7-day post-MI heart. A: representative gelatin zymogram of the infarct zone from 7-day post-MI hearts. MMP-2 and MMP-9 levels were increased over non-MI controls. TSA treatment significantly reduced post-MI MMP-9 expression and activity. B and C: gelatinographic active MMP-2 (B) and MMP-9 (C) levels expressed in arbitrary units. Active MMP-2 and MMP-9 levels were increased in the MI group (20- and 32-fold, respectively), and both were drastically reduced with TSA administration. *P < 0.05 vs. non-MI control; #P < 0.05 vs. MI + vehicle.