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. 2015 Mar 20;308(11):H1391–H1401. doi: 10.1152/ajpheart.00390.2014

Fig. 6.

Fig. 6.

HDAC activity and class I HDAC expression in the infarct zone of the 7-day post-MI heart. A: class I and II HDAC enzymatic activity was measured in 7-day post-MI mouse heart homogenates from the infarct region. Class I HDAC activity was increased at least fourfold in the MI heart compared with the control heart, whereas class II HDAC activity was not significantly altered. B: tissue homogenates from the 7-day post-MI heart were immunoblotted for HDAC1, HDAC2, HDAC3, and GAPDH. C: class I HDAC activity was quantified from 7-day post-MI mouse heart homogenates before and after pan-HDAC inhibitor (SAHA, 1 μM) and class I-specific HDAC inhibitor (PD-106, 5 μM) in vitro treatment. *P < 0.05 vs. non-MI control; #P < 0.05 vs. MI + vehicle.